Pseudomonas Exotoxin A: optimized by evolution for effective killing
نویسندگان
چکیده
Pseudomonas Exotoxin A (PE) is the most toxic virulence factor of the pathogenic bacterium Pseudomonas aeruginosa. This review describes current knowledge about the intoxication pathways of PE. Moreover, PE represents a remarkable example for pathoadaptive evolution, how bacterial molecules have been structurally and functionally optimized under evolutionary pressure to effectively impair and kill their host cells.
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2015